Brains On-Line is a contract research company in neurochemistry, with laboratories located in Groningen (the Netherlands) and San Francisco. Brains On-Line facilitates preclinical drug development for medications aimed at disorders of the CNS, in particular neuropsychological disorders and neurodegenerative disorders. The studies the company carries out include: proof of principle, dose effectiveness, pharmacokinetic and pharmacodynamic relationships, bioavailability, and drug interactions/metabolism. Brains On-Line specializes in monitoring dynamic neurochemical parameters in vivo and in freely-moving models.