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Charles River Laboratories International Inc.
Charles River has been operating since 1947 and during that time, it has undergone several changes to its business structure. Charles River Laboratories International, Inc., incorporated in 1994, is leading global provider of solutions that accelerate the drug discovery and development process, including research models and associated services, and outsourced preclinical services. In 2000, the Company completed the initial public offering of Charles River Laboratories International, Inc.

Acquired Companies: Inveresk Research Group, Inc., MIR Preclinical Services
Phone:781-222-6000
Fax:978-988-9236
Email:askcharlesriver@crl.com
Website:http://www.criver.com/
Address:251 Ballardvale StreetWilmington, MA 01887-1000
  • China
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  • Australia
  • Finland
  • France
  • Germany
  • Hungary
  • India
  • Ireland
  • Italy
  • Japan
  • South Korea
  • Spain
  • United Kingdom
  • USA
ANALYTICAL
Sample Type
Dosage formToxicology
Service Type
MethodsMethod DevelopmentTests - Protein/Peptide/DNA/OligoProtein Biophysical CharacterizationTests - StabilityAccelerated StabilityStability Storage (I/II)Stability Testing (I/II)Tests/Analysis - OtherAssay/PotencyRadiolabel Analysis
API/BIOLOGICS/REAGENTS
API Development Stage
DiscoveryGMP clinicalGMP commercialPreclinical
API Services
Cell Bank ManufacturingCell Therapy
API Types
BiologicsAntibodyVaccine
BIO-ANALYTICAL
Services
Assays and SuppliesBioassaysCell CultureGeneticHematology, CoagulationRadioassaysRadioimmunoassaysCell TherapyDiscovery SupportElisa/Western BlotGeneralMethods Development and ValidationMethods Development/ValidationMicrobiologyGMP-GLPBioanalytical GLPBioanalytical GMPImmunoassayImmuno BiomarkersMetabolite IdentificationMicrodosingPCR
CLINICAL DEVELOPMENT
Clinical Services Provided
Data/IT/StatisticsBiostatisticsMedical Monitoring/SafetyMedical WritingProject ManagementProtocol DevelopmentRegulatory/Quality/SafetyQuality AssuranceSafety/PharmacovigilanceSite/Study/InvestigatorPatient Recruitment/Retention
Clinical Study Type
Bioavailability/BioequivalenceBiomarkersPharmacology/PathologyClinical PathologyPhase 1 to 2First-in-Human StudiesPhase IPhase IIPhase 3PK/PDSafety/TolerabilitySpecialized StudiesDrug Drug InteractionsFood EffectMicro dosingRadio-Labeled Studies
CONSULTANT
Areas of Expertise
BD/HR/IT/Legal
DISCOVERY/PRECLINICAL
Discovery Services
BiogeneticMammalian cell linesNucleic acid IsolationBiomarkersBiomarker AnalysisCell AssaysHigh throughput screeningPreclinicalEfficacy TestingEfficacy In vitroEfficacy In vivoViral Load
Therapeutic Areas
Anesthesia/PainAntiinflammatory/ImmuneBiologicsBlood & CoagulationCancerCardiovascularCNSEndocrine/MetabolismEye DiseasesGastrointestinalInfectious DiseasesMedical DevicesRespiratoryVaccinesWound Care
PHARMACOKINETICS
Service Types ADME
ADME computer predictionADME- In vitroADME/PK Radioactive animalsADME/PK Radioactive humanADME/PK-HumansADME/PK-In vivoCaCo-2In vitro absorption modelsIn Vitro MetabolismIn vivo absorption modelsPK/PD Modelling
TOXICOLOGY
Formulations Category-Toxicology
Biologic FormulationsCytotoxic FormulationsHigh Potency Drug FormulationsInhalation/NasalInjectableOpthalmicOralTopicalTransdermalVaginalViral vectors
Toxicology Services
Acute ToxCarcinogenicityChronic ToxClinical PathologyDermal Hypersensitive & Irritation TestEye IrritationGenetic ToxHistologyImmunotoxIn Vitro ToxIn vivo ToxPathologyPhototoxicityRepeat Dose/Sub-AcuteReproductive & Develop.ToxSafety PharmacologySubchronic ToxToxicokineticsVaginal IrritationVirology
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