Horizon Discovery is striving to provide drug discovery researchers with key missing tools that will accelerate the search for new and more effective ‘targeted’ or ‘personalised’ drugs. Central to realizing this vision is the creation and utilisation of genetically-defined ‘isogenic’ cell-lines, which represent accurate laboratory based models of human genetic diseases and their matched normal cell-types. Isogenic cell-lines speed-up and reduce the cost of discovering novel ‘personalised’ drugs that target the fundamental causes of diseases such as cancer.