NEWS DETAIL

Lonza Announces Broad Selection of High-Resolution HLA-Typed Primary Cell Lots to Support Biologic Drug Research

Basel, Switzerland, 10 November 2020 – Lonza has announced that it now provides an expansive selection of high-resolution Human Leukocyte Antigen (HLA)-typed primary cells spanning all major cell and tissue types. The ready-typed lots will eliminate the need for burdensome in-house sequencing processes and provide drug developers with a critical tool for the more effective development of personalized therapies. Nearly 50 different cell types are available from Lonza’s broad donor inventory, with detailed HLA data derived from gold-standard next-generation sequencing techniques. The new offering builds on Lonza’s renowned human primary cell capabilities to meet rapidly growing market demand for deeper and more comprehensive cell characterization.

A person’s HLA type is a key determinant of the immune system’s response to foreign substances. HLA data is critical for preclinical exploration of cross-reactivities and off-target drug effects. HLA information is also needed for the development of engineered biotherapeutic T cell receptors and antibodies, better patient stratification to optimize the clinical effectiveness of cancer therapies, and is fundamental for the development of new cancer vaccines. As such, there is a rapidly growing market need for high-quality HLA-typed primary cells.

However, screening cell lots for HLA type can be lengthy and cumbersome to conduct in-house, and there is no guarantee that unscreened purchased lots will be the desired HLA type. Further, many vendors are only able to offer lots with lower-resolution HLA information obtained from serological typing methods, which can lead to incomplete HLA matching and poorer predictivity of in vitro models as a result. Being able to select lots with the desired high-resolution HLA data, thus confidently enables a time- and cost-efficient preclinical development and boosts chances of drug development success.

Having previously offered HLA-typing services to its customers on a custom basis, Lonza is now providing high-resolution HLA information at no additional cost for a wide selection of its cell lots. With a diverse donor inventory that includes different age groups, genders, and ethnicities, a broad range of donor cell lots with various HLA types are currently available, including HLA-A2*01.

To find out more about Lonza’s broad range of high-resolution HLA-typed human primary cell lots, please visit: https://bioscience.lonza.com/hla-typed-cells

About Lonza

At Lonza, we combine technological innovation with world class manufacturing and process excellence. Together, these enable our customers to deliver their discoveries in the healthcare, preservation, and protection sectors.

We are a preferred global partner to the pharmaceutical, biotech and specialty ingredients markets. We work to prevent illness and promote a healthier world by enabling our customers to deliver innovative medicines that help treat or even cure a wide range of diseases. We also offer a broad range of microbial control solutions, which help to create and maintain a healthy environment.

Founded in 1897 in the Swiss Alps, Lonza today operates in 120 sites and offices in more than 35 countries. With approximately 15,500 full-time employees, we are built from high-performing teams and of individual employees who make a meaningful difference to our own business, as well as the communities in which we operate. The company generated sales of CHF 5.9 billion in 2019 with a CORE EBITDA of CHF 1.6 billion. Find out more at www.lonza.com and follow us on Twitter @LonzaGroup or Facebook @LonzaGroupAG.

Lonza Contact Details:

Dr. Sanna Fowler
Head of External Communications
Lonza Group Ltd
Tel 41 61 316 8929
[email protected]

Dirk Oehlers
Investor Relations
Lonza Group Ltd
Tel 41 79 421 1609

Additional Information and Disclaimer for Lonza

Lonza Group Ltd has its headquarters in Basel, Switzerland, and is listed on the SIX Swiss Exchange. It has a secondary listing on the Singapore Exchange Securities Trading Limited (“SGX-ST”). Lonza Group Ltd is not subject to the SGX-ST’s continuing listing requirements but remains subject to Rules 217 and 751 of the SGX-ST Listing Manual.

Certain matters discussed in this news release may constitute forward-looking statements. These statements are based on current expectations and estimates of Lonza Group Ltd, although Lonza Group Ltd can give no assurance that these expectations and estimates will be achieved. Investors are cautioned that all forward-looking statements involve risks and uncertainty and are qualified in their entirety. The actual results may differ materially in the future from the forward-looking statements included in this news release due to various factors. Furthermore, except as otherwise required by law, Lonza Group Ltd disclaims any intention or obligation to update the statements contained in this news release.